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1

Enantioselective Conjugate Radical Addition to β-Acyloxy Acrylate Acceptors: An Approach to Acetate Aldol-Type Products

Mukund P. Sibi, Jake Zimmerman, Tara Rheault

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 99 KB

english, 2003

2

Enantioselective Conjugate Radical Addition to β-Acyloxy Acrylate Acceptors: An Approach to Acetate Aldol-Type Products

Mukund P. Sibi, Jake Zimmerman, Tara Rheault

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 100 KB

english, 2003

3

ChemInform Abstract: Higher Selectivity at Higher Temperatures! Effect of Precursor Stereochemistry on Diastereoselectivity in Radical Allylations. Insight into the Role of the Lewis Acid.

Mukund P. Sibi, Tara R. Rheault

Journal:

Year:

2001

Language:

english

File:

PDF, 44 KB

english, 2001

4

ChemInform Abstract: Radical-Mediated Annulation Reactions. A Versatile Strategy for the Preparation of a Series of Carbocycles.

Mukund P. Sibi, Jianxie Chen, Tara R. Rheault

Journal:

Year:

2002

File:

PDF, 32 KB

2002

5

ChemInform Abstract: Acyclic Diastereoselection in Prochiral Radical Addition to Prochiral Olefins.

Mukund P. Sibi, Tara R. Rheault, Sithamalli V. Chandramouli, Craig P. Jasperse

Journal:

Year:

2002

File:

PDF, 36 KB

2002

6

Radical-Mediated Annulation Reactions

Tara R. Rheault, Mukund P. Sibi

Journal:

Year:

2003

File:

PDF, 54 KB

2003

7

Enantioselective Conjugate Radical Addition to β-Acyloxy Acrylate Acceptors: An Approach to Acetate Aldol-Type Products.

Mukund P. Sibi, Jake Zimmerman, Tara Rheault

Journal:

Year:

2004

File:

PDF, 153 KB

2004

8

Synthesis of Oxacycles by Tandem Radical Addition—Cyclization Reactions.

Mukund P. Sibi, Kalyani Patil, Tara R. Rheault

Journal:

Year:

2004

File:

PDF, 204 KB

2004

9

ChemInform Abstract: Convenient Synthesis of Heteroaryl-Linked Benzimidazoles via Microwave-Assisted Boronate Ester Formation.

Tara R. Rheault, Kelly H. Donaldson, Mui Cheung

Journal:

Year:

2009

File:

PDF, 42 KB

2009

10

Synthesis of Oxacycles by Tandem Radical Addition−Cyclization Reactions

Mukund P. Sibi, Kalyani Patil, Tara R. Rheault

Journal:

European Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 220 KB

english, 2004

11

Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors

Tara R. Rheault, Thomas R. Caferro, Scott H. Dickerson, Kelly H. Donaldson, Michael D. Gaul, Aaron S. Goetz, Robert J. Mullin, Octerloney B. McDonald, Kimberly G. Petrov, David W. Rusnak, Lisa M. Shew

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.45 MB

english, 2009

12

Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties

Tara R. Rheault, Kelly H. Donaldson, Jennifer G. Badiang-Alberti, Ronda G. Davis-Ward, C. Webb Andrews, Ramesh Bambal, Jeffrey R. Jackson, Mui Cheung

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.00 MB

english, 2010

13

Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup

John C. Stellwagen, George M. Adjabeng, Marc R. Arnone, Scott H. Dickerson, Chao Han, Keith R. Hornberger, Alastair J. King, Robert A. Mook Jr., Kimberly G. Petrov, Tara R. Rheault, Cynthia M. Rominge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 475 KB

english, 2011

14

Convenient synthesis of heteroaryl-linked benzimidazoles via microwave-assisted boronate ester formation

Tara R. Rheault, Kelly H. Donaldson, Mui Cheung

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 847 KB

english, 2009

15

Highly diastereoselective radical addition–cyclization strategy: facile synthesis of substituted furans

Mukund P. Sibi, Tara R. Rheault, Hideto Miyabe, Kalyani Patil, Craig P. Jasperse

Journal:

Comptes Rendus de l'Académie des Sciences - Series IIC - Chemistry

Year:

2001

Language:

english

File:

PDF, 113 KB

english, 2001

16

Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

Rheault, Tara R., Stellwagen, John C., Adjabeng, George M., Hornberger, Keith R., Petrov, Kimberly G., Waterson, Alex G., Dickerson, Scott H., Mook, Robert A., Laquerre, Sylvie G., King, Alastair J.,

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 815 KB

english, 2013

17

Higher Selectivity at Higher Temperatures! Effect of Precursor Stereochemistry on Diastereoselectivity in Radical Allylations. Insight into the Role of the Lewis Acid

Sibi, Mukund P., Rheault, Tara R.

Journal:

Journal of the American Chemical Society

Year:

2000

Language:

english

File:

PDF, 87 KB

english, 2000

18

Acyclic Diastereoselection in Prochiral Radical Addition to Prochiral Olefins

Sibi, Mukund P., Rheault, Tara R., Chandramouli, Sithamalli V., Jasperse, Craig P.

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 103 KB

english, 2002

19

Radical-Mediated Annulation Reactions. A Versatile Strategy for the Preparation of a Series of Carbocycles

Sibi, Mukund P., Chen, Jianxie, Rheault, Tara R.

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 48 KB

english, 2001

20

Discovery of 4-Amino-8-quinoline carboxamides as novel, submicromolar inhibitors of the NAD hydrolyzing enzyme CD38

Becherer, J. David, Boros, Eric E, Carpenter, Tiffany Y., Cowan, David J., Deaton, David, Haffner, Curt D., Jeune, Michael R., Kaldor, Istvan W., Poole, J. Chuck, Preugschat, Frank, Rheault, Tara R, S

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.66 MB

english, 2015

21

Radical-Mediated AnnulationReactions

Rheault, Tara R., Sibi, Mukund P.

Journal:

Year:

2003

Language:

english

File:

PDF, 282 KB

english, 2003

22

A comparison of COPD patients with and without ACOS in the ECLIPSE study

Wurst, Keele E., Rheault, Tara R., Edwards, Lisa, Tal-Singer, Ruth, Agusti, Alvar, Vestbo, Jørgen

Journal:

European Respiratory Journal

Year:

2016

Language:

english

File:

PDF, 298 KB

english, 2016

23

UNIQUE DUAL PHOSPHODIESTERASE 3/4 INHIBITOR, ENSIFENTRINE, SIGNIFICANTLY IMPROVES COPD SYMPTOMS INCLUDING DYSPNEA

Rickard, Kathleen, Rheault, Tara, Maurer, Brian, Singh, Dave

Journal:

Year:

2019

Language:

english

File:

PDF, 98 KB

english, 2019

24

Symptom Improvement Following Treatment with the Inhaled Dual Phosphodiesterase 3 and 4 Inhibitor Ensifentrine in Patients with Moderate to Severe COPD â A Detailed Analysis

Watz, Henrik, Rickard, Kathleen, Rheault, Tara, Bengtsson, Thomas, Singh, Dave

Journal:

International Journal of Chronic Obstructive Pulmonary Disease

Year:

2020

File:

PDF, 2.32 MB

2020

25

ENSIFENTRINE, A NOVEL DUAL PHOSPHODIESTERASE (PDE) 3 AND 4 INHIBITOR, PROVIDES EFFECTIVE BRONCHODILATION WHEN ADMINISTERED BY METERED DOSE INHALER IN PATIENTS WITH COPD

Rheault, Tara, Leaker, Brian, Singh, Dave, Bengtsson, Thomas, Rickard, Kathleen

Journal:

Year:

2020

File:

PDF, 65 KB

2020

26

ANTIINFLAMMATORY PHARMACOLOGY OF ENSIFENTRINE

Rheault, Tara, MacDonald-Berko, Margot

Journal:

Year:

2020

File:

PDF, 63 KB

2020

27

ENSIFENTRINE ADDED TO TIOTROPIUM OVER 4 WEEKS PROVIDES ADDITIONAL IMPROVEMENT IN COPD QUALITY OF LIFE

Rickard, Kathleen, Bengtsson, Thomas, Rheault, Tara

Journal:

Year:

2020

File:

PDF, 67 KB

2020

28

ENSIFENTRINE ADDED ON TO TIOTROPIUM SIGNIFICANTLY IMPROVES INSPIRATORY CAPACITY IN PATIENTS WITH SYMPTOMATIC COPD

Rickard, Kathleen, Bengtsson, Thomas, Rheault, Tara

Journal:

Year:

2020

File:

PDF, 65 KB

2020